Inflammation Adjuvants in Sterile and Septic Heat Shock Proteins as Endogenous
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Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions. We now demonstrate that the endogenous alarmins MRP8 and MRP14 induce phagocyte hyporesponsiveness via chromatin modifications in a TLR4-dependent manner that results in enha...
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